Keywords: polymer vesicles shear-induced cargo release confined shear additive carriers soft nanoadditives figures this is an open access article distributed under the creative commons attribution license which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Because of their low membrane permeability the use of polymeric vesicles in certain drug delivery and molecular imaging applications and as bioreactors is less than ideal.
Vesicles made from amphiphilic copolymers are disclosed the amphiphilic copolymers can be aba copolymers, where one of a and b is hydrophilic and the other is hydrophobic. Multifunctional polymeric vesicles were developed for targeted drug delivery and imaging to fabricate this system, a biodegradable amphiphilic diblock copolymer, folate–poly(ethylene glycol)–poly(d,l-lactide) was designed and synthesized through sequential anionic polymerization in a well. Reduction-cleavable polymeric vesicles with efficient glutathione-mediated drug release behavior for reversing drug resistance advertisement.
A vesicle comprising, as a membrane-forming ingredient, a phosphoric ester represented by the following general formula (2): wherein r¹ means a hydrogen atom or an alkyl group having 1-4 carbon atoms, r² denotes an alkylene group having 1-6 carbon atoms, r³ and r⁴ may be identical to or different from each other and represent individually. Solution-phase assembly of nanoparticles and amphiphilic polymers: controlling the morphology from vesicles to micelles formation of polymer vesicles. Full-text paper (pdf): cargo release from polymeric vesicles under shear. From the national science foundation the polymeric vesicles and vesicle rupturing systems will be discussed in following sections the vesicle rupturing system, which is the main focus of this project, is the second phase of a multiple-stagedevelopment process required to create the vesicle cascade portion ofthe sensor-responsesystem.
Purpose to prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting methods a glucose-palmitoyl glycol chitosan (pgc) conjugate was synthesised and. To achieve effective intracellular anticancer drug delivery, the polymeric vesicles supplemented with the ph-responsive outlayered gels as a delivery system of doxorubicin (dox) were developed from self-assembly of the lipid/polypeptide adduct, distearin grafted poly(γ-glutamic acid) (poly(γ-ga)), followed by sequential deposition of chitosan. Keywords: polymer vesicles shear-induced cargo release conﬁned shear additive carriers soft nanoadditives 1 introduction nano-carriers are nanoscale containers which can enclose small molecules and protect inclusions from reactions with the outer environment or help separate incompatible components in different compartments . Vesicles are microscopic sacs that enclose a volume with a molecularly thin membrane the membranes are generally self-directed assemblies of amphiphilic molecules with a dual hydrophilic-hydrophobic character.
Syracuse university surface physics college of arts and sciences 4-17-2009 smectic polymer vesicles mark bowick department of physics, syracuse university, syracuse, ny. Naturecom search check one or more article types to show results from those article types only. 1 hydrodynamic mobility of confined polymeric particles, vesicles and cancer cells in a square microchannel shamim m ahmmed1+, naureen s suteria1+, valeria garbin2 and siva a vanapalli1.
Vesicles, we coat the sub-100-nm polymeric particles with the bilayered rbc membranes including both lipids and the corre-sponding surface proteins. Multifunctional polymeric vesicles were developed for targeted drug delivery and imaging to fabricate this system, a biodegradable amphiphilic diblock copolymer.
Polymeric vesicles, with the ability to transport drugs or genes, are prepared in one of two ways: i) the self-assembly of amphiphilic polymers and ii) the polymerisation of monomers, following self-assembly (polymerised vesicles). Of oxidation-responsive polymeric vesicles may find applications as nanocontainers in drug delivery, biosensing and biodetection oxidation-responsive polymeric vesicles. Polymeric vesicles, or polymersomes, are nano- to micrometre sized polymeric capsules with a bilayered membrane applications of these vesicles are foreseen in nanomedicine, in vivo imaging and drug delivery these applications put many restrictions on the choice of polymer, the size and the surface of the vesicle. Hydrolysis-triggered controlled release vesicles controlled release polymer vesicles are prepared using hydrolysable diblock copolymers of polyethyleneglycol.Download